Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Proteolysis‐targeting chimeras in drug development: A safety perspective - Moreau - 2020 - British Journal of Pharmacology - Wiley Online Library
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics | Oncogene
The Power of PROTACs - LifeSensors
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
Proteolysis‐targeting chimeras in drug development: A safety perspective - Moreau - 2020 - British Journal of Pharmacology - Wiley Online Library
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
An AURKA PROTAC cocktail relieves the hook effect. A) Scheme depicting... | Download Scientific Diagram
PROTACs: Current Trends in Protein Degradation by Proteolysis-Targeting Chimeras | BioDrugs
Targeted protein degradation in cancers: Orthodox PROTACs and beyond. - Abstract - Europe PMC
Current strategies for improving limitations of proteolysis targeting chimeras - ScienceDirect
Pharmaceutics | Free Full-Text | A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)
PROTAC® Ubiquitination Assays - LifeSensors
Biomolecules | Free Full-Text | Central Nervous System Targeted Protein Degraders
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Allosteric modulators can exacerbate the hook effect by reducing... | Download Scientific Diagram
PROTAC-mediated ternary complex formation and hook effect. The hook... | Download Scientific Diagram
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins | Journal of Medicinal Chemistry
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Ingo Hartung on X: "Concise summary of 1st principles for #PROTAC design/characterization (@C4Therapeutics): Affinity (ternary complexes, cooperativity, Hook effect) AND catalytic efficiency (Kcat for target ubiquitination, degradation efficiency) rule ...
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Pharmaceutics | Free Full-Text | Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
Delineating the role of cooperativity in the design of potent PROTACs for BTK | PNAS
The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation - Chemical Society Reviews (RSC Publishing) DOI:10.1039/D2CS00339B
Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras | Science Advances
